When the fourth film was announced, Reeves was reportedly revealed to have begun his training course for John Wick 4 and The Matrix 4

In early August 2020, Lionsgate CEO Jon Feltheimer stated during an earnings call, “We’re also busy preparing scripts for the next two installments of our John Wick action franchise, with John Wick 4 slated to hit theaters Memorial Day weekend 2022. We hope to shoot both John Wick 4 and 5 back to back when Keanu becomes available early next year.

In May 2021, it was announced that Rina Sawayama would make her feature film debut in John Wick Chapter 4. She was selected due to the role requiring someone who can do choreography, and Stahelski had seen her music videos for “XS” and “Bad Friend” that feature dance and fighting, respectively. The following month, Laurence Fishburne, Hiroyuki Sanada, Donnie Yen, Bill Skarsgård, Shamier Anderson, and Scott Adkins were cast in the film. Sanada was initially courted to portray Zero in Chapter 3, but dropped out in favor of appearing in Avengers: Endgame. In July 2021, Lance Reddick was confirmed to be reprising his role as Charon, and Ian McShane was confirmed to be reprising his role as Winston. Clancy Brown joined the cast that August.